FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
DAAM1
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
123kD
推荐稀释比
WB 1:500-2000;ELISA 1:10000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthetic peptide from human protein at AA range: 400-500
特异性
The antibody detects endogenous DAAM1
基因名称
DAAM1 KIAA0666
蛋白名称
Disheveled-associated activator of morphogenesis 1
别名
Disheveled-associated activator of morphogenesis 1
Organism-1
Human
基因ID-1
23002
SwissProt-1
Q9Y4D1
Organism-2
Mouse
基因ID-2
208846
SwissProt-2
Q8BPM0
背景
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Perinuclear.
