FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
COL25A1
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
64kD
推荐稀释比
WB 1:500-2000;ELISA 1:10000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthetic peptide from human protein at AA range: 101-150
特异性
The antibody detects endogenous COL25A1 protein
基因名称
COL25A1
蛋白名称
collagen, type XXV, alpha 1
别名
COL25A1
Organism-1
Human
基因ID-1
84570
SwissProt-1
Q9BXS0
Organism-2
Mouse
基因ID-2
77018
SwissProt-2
Q99MQ5
背景
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
细胞定位
Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted.
