FGF-2 Polyclonal Antibody
¥680.00
Caspase-1 Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2617477
- 产品信息
商品描述
靶点-Target
Caspase-1
反应性
Human,Mouse,Rat
应用
IF,WB,IHC,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
45kD
MW(Observed)
45kD,35kD,cleaced isform p10 :10kD
推荐稀释比
IF 1:50-200;WB 1:500-2000;IHC 1:50-300;ELISA 1:10000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400
特异性
Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1
基因名称
CASP1 IL1BC IL1BCE
蛋白名称
Caspase1
别名
caspase 1, apoptosis-related cysteine peptidase;interleukin 1, beta, convertase;
Organism-1
Human
基因ID-1
834
SwissProt-1
P29466
Organism-2
Mouse
基因ID-2
12362
SwissProt-2
P29452
Organism-3
Rat
SwissProt-3
P43527
背景
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],
细胞定位
Cytoplasm . Cell membrane .
