FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PPP1R15B
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
78kD
推荐稀释比
WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human PPP1R15B. AA range:411-460
特异性
PPP1R15B Polyclonal Antibody detects endogenous levels of PPP1R15B protein.
基因名称
PPP1R15B
蛋白名称
Protein phosphatase 1 regulatory subunit 15B
别名
PPP1R15B;Protein phosphatase 1 regulatory subunit 15B
Organism-1
Human
基因ID-1
84919
SwissProt-1
Q5SWA1
Organism-2
Mouse
SwissProt-2
Q8BFW3
背景
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with mi
细胞定位
protein phosphatase type 1 complex,
