FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
11β-HSD1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
35kD
推荐稀释比
WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from 11β-HSD1 . at AA range: 20-50
特异性
11β-HSD1 Polyclonal Antibody detects endogenous levels of 11β-HSD1 protein.
基因名称
HSD11B1
蛋白名称
Corticosteroid 11-beta-dehydrogenase isozyme 1
别名
HSD11B1;HSD11;HSD11L;Corticosteroid 11-beta-dehydrogenase isozyme 1;11-beta-hydroxysteroid dehydrogenase 1;11-DH;11-beta-HSD1
Organism-1
Human
基因ID-1
3290
SwissProt-1
P28845
Organism-2
Mouse
基因ID-2
15483
SwissProt-2
P50172
Organism-3
Rat
基因ID-3
25116
SwissProt-3
P16232
背景
hydroxysteroid 11-beta dehydrogenase 1(HSD11B1) Homo sapiens The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011],
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
