FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CO4 A/B
反应性
Human
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
180kD
推荐稀释比
WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human C4A/C4B. AA range:721-770
特异性
C4a/b Polyclonal Antibody detects endogenous levels of C4a/b protein.
基因名称
C4A/C4B
蛋白名称
Complement C4-A/Complement C4-B
别名
C4A;CO4;CPAMD2;Complement C4-A;Acidic complement C4;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2;C4B;CO4;CPAMD3;Complement C4-B;Basic complement C4;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
Organism-1
Human
基因ID-1
720;721
SwissProt-1
P0C0L4;P0C0L5
背景
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided
细胞定位
Secreted. Cell junction, synapse . Cell projection, axon . Cell projection, dendrite .
