FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Androgen Receptor
反应性
Human,Mouse,Rat
应用
IF,WB,IHC,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
99kD
推荐稀释比
IF 1:50-200;WB 1:500-2000;ELISA 1:10000-20000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from the Internal region of human AR.
特异性
AR Polyclonal Antibody detects endogenous levels of AR protein.
基因名称
AR
蛋白名称
Androgen receptor
别名
AR;DHTR;NR3C4;Androgen receptor;Dihydrotestosterone receptor;Nuclear receptor subfamily 3 group C member 4
Organism-1
Human
基因ID-1
367
SwissProt-1
P10275
Organism-2
Mouse
基因ID-2
11835
SwissProt-2
P19091
Organism-3
Rat
基因ID-3
24208
SwissProt-3
P15207
背景
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform
细胞定位
Nucleus . Cytoplasm . Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. .
