FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MCM6
反应性
Human,Mouse,Rat
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
90kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human MCM6. AA range:331-380
特异性
MCM6 Polyclonal Antibody detects endogenous levels of MCM6 protein.
基因名称
MCM6
蛋白名称
DNA replication licensing factor MCM6
别名
MCM6;DNA replication licensing factor MCM6;p105MCM
Organism-1
Human
基因ID-1
4175
SwissProt-1
Q14566
Organism-2
Mouse
基因ID-2
17219
SwissProt-2
P97311
Organism-3
Rat
SwissProt-3
Q62724
背景
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, i
细胞定位
Nucleus . Chromosome . Binds to chromatin during G1 and detach from it during S phase. .
