FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
APAF1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
135kD
推荐稀释比
WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human APAF1. AA range:501-550
特异性
Apaf-1 Polyclonal Antibody detects endogenous levels of Apaf-1 protein.
基因名称
APAF1
蛋白名称
Apoptotic protease-activating factor 1
别名
APAF1;KIAA0413;Apoptotic protease-activating factor 1;APAF-1
Organism-1
Human
基因ID-1
317
SwissProt-1
O14727
Organism-2
Mouse
基因ID-2
11783
SwissProt-2
O88879
Organism-3
Rat
基因ID-3
78963
SwissProt-3
Q9EPV5
背景
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm .
