FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
SLAM
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
37kD
推荐稀释比
WB 1:500-1:2000;IHC: 1:100-300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human SLAMF1. AA range:81-130
特异性
SLAM Polyclonal Antibody detects endogenous levels of SLAM protein.
基因名称
SLAMF1
蛋白名称
Signaling lymphocytic activation molecule
别名
SLAMF1;SLAM;Signaling lymphocytic activation molecule;CDw150;IPO-3;CD150
Organism-1
Human
基因ID-1
6504
SwissProt-1
Q13291
Organism-2
Mouse
基因ID-2
27218
SwissProt-2
Q9QUM4
背景
domain:The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.,function:High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.,PTM:Phosphorylated by FYN.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subcellular location:Present on the surface of B-cells and T-cells.,subunit:Its cytoplasmic domain interacts with SH2 domain protein 1A (SH2D1A), and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus HN protein and acts as a receptor for this virus.,tissue specificity:Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes, and a proportion of B-cells, and is rapidely induced on naive T-cells after activation.,
细胞定位
Cell membrane ; Single-pass type I membrane protein. Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999). .; [Isoform 3]: Secreted .; [Isoform 4]: Cell membrane . Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers. .
