FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
VHR
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
21kD
推荐稀释比
WB 1:500-1:2000;IHC: 1:100-300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human DUSP3. AA range:136-185
特异性
VHR Polyclonal Antibody detects endogenous levels of VHR protein.
基因名称
DUSP3
蛋白名称
Dual specificity protein phosphatase 3
别名
DUSP3;VHR;Dual specificity protein phosphatase 3;Dual specificity protein phosphatase VHR;Vaccinia H1-related phosphatase;VHR
Organism-1
Human
基因ID-1
1845
SwissProt-1
P51452
Organism-2
Mouse
基因ID-2
72349
SwissProt-2
Q9D7X3
背景
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast ca
细胞定位
Nucleus .
