FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Angptl4
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
45kD
推荐稀释比
IHC: 100-300;WB 1:500-1:2000;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human ANGPTL4. AA range:301-350
特异性
Angptl4 Polyclonal Antibody detects endogenous levels of Angptl4 protein.
基因名称
ANGPTL4
蛋白名称
Angiopoietin-related protein 4
别名
ANGPTL4;ARP4;HFARP;PGAR;PP1158;PSEC0166;Angiopoietin-related protein 4;Angiopoietin-like protein 4;Hepatic fibrinogen/angiopoietin-related protein;HFARP
Organism-1
Human
基因ID-1
51129
SwissProt-1
Q9BY76
Organism-2
Mouse
基因ID-2
57875
SwissProt-2
Q9Z1P8
Organism-3
Rat
基因ID-3
362850
SwissProt-3
Q6TMA8
背景
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013],
细胞定位
Secreted . Secreted, extracellular space, extracellular matrix . The unprocessed form interacts with the extracellular matrix (PubMed:17068295, PubMed:21398697). This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (Probable). .
