FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
NF90
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
95kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human NF90. AA range:302-351
特异性
NF90 Polyclonal Antibody detects endogenous levels of NF90 protein.
基因名称
ILF3
蛋白名称
Interleukin enhancer-binding factor 3
别名
ILF3;DRBF;MPHOSPH4;NF90;Interleukin enhancer-binding factor 3;Double-stranded RNA-binding protein 76;DRBP76;M-phase phosphoprotein 4;MPP4;Nuclear factor associated with dsRNA;NFAR;Nuclear factor of activated T-cells 90 kDa;NF-AT-90;Translational control protein 80;TCP80
Organism-1
Human
基因ID-1
3609
SwissProt-1
Q12906
Organism-2
Mouse
基因ID-2
16201
SwissProt-2
Q9Z1X4
Organism-3
Rat
基因ID-3
84472
SwissProt-3
Q9JIL3
背景
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014],
细胞定位
Nucleus, nucleolus . Cytoplasm . Nucleus . Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .
