FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
VEGF-A
反应性
Human,Mouse,Rat,Pig,Rabbit
应用
WB,IF,IHC,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
21kD(monomer),42kD(dimer)
推荐稀释比
WB 1:500-1:2000.IF 1:50-200;IHC 1:100-1:300;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human VEGF-A. AA range:110-159
特异性
VEGF-A Polyclonal Antibody detects endogenous levels of VEGF-A protein.
基因名称
VEGFA
蛋白名称
Vascular endothelial growth factor A
别名
VEGFA;VEGF;Vascular endothelial growth factor A;VEGF-A;Vascular permeability factor;VPF
Organism-1
Human
基因ID-1
7422
SwissProt-1
P15692
Organism-2
Mouse
基因ID-2
22339
SwissProt-2
Q00731
Organism-3
Rat
基因ID-3
83785
SwissProt-3
P16612
背景
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation fro
细胞定位
Secreted . VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
