FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
TRAP230
反应性
Human,Mouse
应用
IHC,IF,WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
247kD
推荐稀释比
WB 1:500-2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MED12. AA range:611-660
特异性
TRAP230 Polyclonal Antibody detects endogenous levels of TRAP230 protein.
基因名称
MED12
蛋白名称
Mediator of RNA polymerase II transcription subunit 12
别名
MED12;ARC240;CAGH45;HOPA;KIAA0192;TNRC11;TRAP230;Mediator of RNA polymerase II transcription subunit 12;Activator-recruited cofactor 240 kDa component;ARC240;CAG repeat protein 45;Mediator complex subunit 12;OPA-containing prote
Organism-1
Human
基因ID-1
9968
SwissProt-1
Q93074
Organism-2
Mouse
SwissProt-2
A2AGH6
背景
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009],
细胞定位
Nucleus .
