FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
tPA
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
63kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human tPA. AA range:38-87
特异性
tPA Polyclonal Antibody detects endogenous levels of tPA protein.
基因名称
PLAT
蛋白名称
Tissue-type plasminogen activator
别名
PLAT;Tissue-type plasminogen activator;t-PA;t-plasminogen activator;tPA;Alteplase;Reteplase
Organism-1
Human
基因ID-1
5327
SwissProt-1
P00750
Organism-2
Mouse
基因ID-2
18791
SwissProt-2
P11214
Organism-3
Rat
基因ID-3
25692
SwissProt-3
P19637
背景
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
细胞定位
Secreted, extracellular space.
