FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Topo IIβ
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
183kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human TOP2B. AA range:1-50
特异性
Topo IIβ Polyclonal Antibody detects endogenous levels of Topo IIβ protein.
基因名称
TOP2B
蛋白名称
DNA topoisomerase 2-beta
别名
TOP2B;DNA topoisomerase 2-beta;DNA topoisomerase II;beta isozyme
Organism-1
Human
基因ID-1
7155
SwissProt-1
Q02880
Organism-2
Mouse
基因ID-2
21974
SwissProt-2
Q64511
背景
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla
细胞定位
Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus .
