FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
TIF1α
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
117kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human TRIM24. AA range:1001-1050
特异性
TIF1α Polyclonal Antibody detects endogenous levels of TIF1α protein.
基因名称
TRIM24
蛋白名称
Transcription intermediary factor 1-alpha
别名
TRIM24;RNF82;TIF1;TIF1A;Transcription intermediary factor 1-alpha;TIF1-alpha;E3 ubiquitin-protein ligase TRIM24;RING finger protein 82;Tripartite motif-containing protein 24
Organism-1
Human
基因ID-1
8805
SwissProt-1
O15164
Organism-2
Mouse
基因ID-2
21848
SwissProt-2
Q64127
背景
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Cytoplasm . Mitochondrion . Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear. Translocated from nucleus to mitochondria to mediate antiviral immunity (PubMed:32324863). .
