FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Tensin3
反应性
Human,Mouse
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
155kD
推荐稀释比
IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human TENS3. AA range:541-590
特异性
Tensin3 Polyclonal Antibody detects endogenous levels of Tensin3 protein.
基因名称
TNS3
蛋白名称
Tensin-3
别名
TNS3;TEM6;TENS1;TPP;Tensin-3;Tensin-like SH2 domain-containing protein 1;Tumor endothelial marker 6
Organism-1
Human
基因ID-1
64759
SwissProt-1
Q68CZ2
Organism-2
Mouse
SwissProt-2
Q5SSZ5
背景
function:May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development.,induction:EGF induces down-regulation.,PTM:Epidermal growth factor(EGF) induces tyrosine phosphorylation in a time- and dose-dependent manner.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subunit:EGF promotes the interaction with EGFR. Interacts with PTK2 and BCAR1. Tyrosine phosphorylation is critical for these interactions.,tissue specificity:Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.,
细胞定位
Cell junction, focal adhesion .
