FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Strad
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
46kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human STRAD. AA range:11-60
特异性
Strad Polyclonal Antibody detects endogenous levels of Strad protein.
基因名称
STRADA
蛋白名称
STE20-related kinase adapter protein alpha
别名
STRADA;LYK5;STRAD;STE20-related kinase adapter protein alpha;STRAD alpha;STE20-related adapter protein;Serologically defined breast cancer antigen NY-BR-96
Organism-1
Human
基因ID-1
92335
SwissProt-1
Q7RTN6
Organism-2
Mouse
基因ID-2
72149
SwissProt-2
Q3UUJ4
背景
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a ' pseudokinase' . The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009],
细胞定位
Nucleus . Cytoplasm .
