FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Stat1
反应性
Human,Mouse,Rat,Chicken
应用
IF,WB,IHC,IP,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
87kD
推荐稀释比
IF 1:50-200;WB 1:500-1:2000;IHC 1:100-1:300;IP 1:200;ELISA 1:10000;Not yet tested in other applications;
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human STAT1. AA range:694-743
特异性
Stat1 Polyclonal Antibody detects endogenous levels of Stat1 protein.
基因名称
STAT1
蛋白名称
Signal transducer and activator of transcription 1-alpha/beta
别名
STAT1;Signal transducer and activator of transcription 1-alpha/beta;Transcription factor ISGF-3 components p91/p84
Organism-1
Human
基因ID-1
6772
SwissProt-1
P42224
Organism-2
Mouse
SwissProt-2
P42225
背景
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Nucleus . Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788). .
