FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
SOCS-1
反应性
Human,Mouse,Rat
应用
IF,WB,IHC,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
38kD
推荐稀释比
IF 1:50-200;WB 1:500-2000;ELISA 1:10000-20000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SOCS-1. AA range:49-98
特异性
SOCS-1 Polyclonal Antibody detects endogenous levels of SOCS-1 protein.
基因名称
SOCS1
蛋白名称
Suppressor of cytokine signaling 1
别名
SOCS1;SSI1;TIP3;Suppressor of cytokine signaling 1;SOCS-1;JAK-binding protein;JAB;STAT-induced STAT inhibitor 1;SSI-1;Tec-interacting protein 3;TIP-3
Organism-1
Human
基因ID-1
8651
SwissProt-1
O15524
Organism-2
Mouse
基因ID-2
12703
SwissProt-2
O35716
Organism-3
Rat
基因ID-3
252971
SwissProt-3
Q9QX78
背景
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Cytoplasmic vesicle . Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
