FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
SHPS1
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
55kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Sirp alpha1. AA range:451-500
特异性
SIRP-α1 Polyclonal Antibody detects endogenous levels of SIRP-α1 protein.
基因名称
SIRPA
蛋白名称
Tyrosine-protein phosphatase non-receptor type substrate 1
别名
SIRPA;BIT;MFR;MYD1;PTPNS1;SHPS1;SIRP;Tyrosine-protein phosphatase non-receptor type substrate 1;SHP substrate 1;SHPS-1;Brain Ig-like molecule with tyrosine-based activation motifs;Bit;CD172 antigen-like family member A;Inhibito
Organism-1
Human
基因ID-1
140885
SwissProt-1
P78324
Organism-2
Mouse
基因ID-2
19261
SwissProt-2
P97797
Organism-3
Rat
基因ID-3
25528
SwissProt-3
P97710
背景
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternati
细胞定位
Membrane; Single-pass type I membrane protein.
