FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
QIK/QSK
反应性
Human,Rat
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
85kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SIK. AA range:148-197
特异性
SIK1 Polyclonal Antibody detects endogenous levels of SIK1 protein.
基因名称
SIK1
蛋白名称
Serine/threonine-protein kinase SIK1
别名
SIK1;SIK;SNF1LK;Serine/threonine-protein kinase SIK1;Salt-inducible kinase 1;SIK-1;Serine/threonine-protein kinase SNF1-like kinase 1;Serine/threonine-protein kinase SNF1LK
Organism-1
Human
基因ID-1
150094
SwissProt-1
P57059
Organism-2
Mouse
SwissProt-2
Q60670
Organism-3
Rat
基因ID-3
59329
SwissProt-3
Q9R1U5
背景
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.,
细胞定位
Cytoplasm . Nucleus . Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).
