FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Siah-1/2
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
34kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SIAH1. AA range:181-230
特异性
Siah-1/2 Polyclonal Antibody detects endogenous levels of Siah-1/2 protein.
基因名称
SIAH1/SIAH2
蛋白名称
E3 ubiquitin-protein ligase SIAH1/2
别名
SIAH1;HUMSIAH;E3 ubiquitin-protein ligase SIAH1;Seven in absentia homolog 1;Siah-1;Siah-1a;SIAH2;E3 ubiquitin-protein ligase SIAH2;Seven in absentia homolog 2;Siah-2;hSiah2
Organism-1
Human
基因ID-1
6477;6478
SwissProt-1
Q8IUQ4;O43255
Organism-2
Mouse
基因ID-2
20439
Organism-3
Rat
基因ID-3
140941;140593
SwissProt-3
Q920M9;Q8R4T2
背景
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear.
