FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Shank 2
反应性
Human,Rat,Mouse,
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
135kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SHANK2. AA range:331-380
特异性
Shank 2 Polyclonal Antibody detects endogenous levels of Shank 2 protein.
基因名称
SHANK2
蛋白名称
SH3 and multiple ankyrin repeat domains protein 2
别名
SHANK2;CORTBP1;KIAA1022;SH3 and multiple ankyrin repeat domains protein 2;Shank2;Cortactin-binding protein 1;CortBP1;Proline-rich synapse-associated protein 1
Organism-1
Human
基因ID-1
22941
SwissProt-1
Q9UPX8
Organism-2
Mouse
SwissProt-2
Q80Z38
背景
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],
细胞定位
Apical cell membrane . Cytoplasm . Cell junction, synapse . Cell junction, synapse, postsynaptic density . Cell projection, growth cone . Cell projection, dendritic spine . Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity). .
