FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Separase
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
230kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:40000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SEPARASE. AA range:767-816
特异性
Separase Polyclonal Antibody detects endogenous levels of Separase protein.
基因名称
ESPL1
蛋白名称
Separin
别名
ESPL1;ESP1;KIAA0165;Separin;Caspase-like protein ESPL1;Extra spindle poles-like 1 protein;Separase
Organism-1
Human
基因ID-1
9700
SwissProt-1
Q14674
Organism-2
Mouse
基因ID-2
105988
SwissProt-2
P60330
背景
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010],
细胞定位
Cytoplasm. Nucleus.
