FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
SENP6
反应性
Human,Mouse
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
126kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SENP6. AA range:1042-1091
特异性
SENP6 Polyclonal Antibody detects endogenous levels of SENP6 protein.
基因名称
SENP6
蛋白名称
Sentrin-specific protease 6
别名
SENP6;KIAA0797;SSP1;SUSP1;FKSG6;Sentrin-specific protease 6;SUMO-1-specific protease 1;Sentrin/SUMO-specific protease SENP6
Organism-1
Human
基因ID-1
26054
SwissProt-1
Q9GZR1
Organism-2
Mouse
SwissProt-2
Q6P7W0
背景
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for
细胞定位
Nucleus .
