FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Sck
反应性
Human,Rat
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
59kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310
特异性
Sck Polyclonal Antibody detects endogenous levels of Sck protein.
基因名称
SHC2
蛋白名称
SHC-transforming protein 2
别名
SHC2;SCK;SHCB;SHC-transforming protein 2;Protein Sck;SHC-transforming protein B;Src homology 2 domain-containing-transforming protein C2;SH2 domain protein C2
Organism-1
Human
基因ID-1
25759
SwissProt-1
P98077
Organism-2
Mouse
SwissProt-2
Q8BMC3
Organism-3
Rat
基因ID-3
314612
SwissProt-3
O70142
背景
domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,
细胞定位
intracellular,cytosol,plasma membrane,
