FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ROM-K
反应性
Human,Mouse,Rat
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
45kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human ROMK/Kir1.1. AA range:11-60
特异性
ROM-K Polyclonal Antibody detects endogenous levels of ROM-K protein.
基因名称
KCNJ1
蛋白名称
ATP-sensitive inward rectifier potassium channel 1
别名
KCNJ1;ROMK1;ATP-sensitive inward rectifier potassium channel 1;ATP-regulated potassium channel ROM-K;Inward rectifier K;+;channel Kir1.1;Potassium channel;inwardly rectifying subfamily J member 1
Organism-1
Human
基因ID-1
3758
SwissProt-1
P48048
Organism-2
Mouse
基因ID-2
56379
SwissProt-2
O88335
Organism-3
Rat
基因ID-3
24521
SwissProt-3
P35560
背景
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Multi-pass membrane protein . Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. .
