FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Rho A
反应性
Human,Mouse,Rat
应用
IF,WB,IHC,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
22kD
推荐稀释比
IF 1:50-200;WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;Not yet tested in other applications;
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human RhoA. AA range:144-193
特异性
Rho A Polyclonal Antibody detects endogenous levels of Rho A protein.
基因名称
RHOA
蛋白名称
Transforming protein RhoA
别名
RHOA;ARH12;ARHA;RHO12;Transforming protein RhoA;Rho cDNA clone 12;h12
Organism-1
Human
基因ID-1
387
SwissProt-1
P61586
Organism-2
Mouse
基因ID-2
11848
SwissProt-2
Q9QUI0
Organism-3
Rat
基因ID-3
117273
SwissProt-3
P61589
背景
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],
细胞定位
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex . Midbody. Cell projection, lamellipodium . Cell projection, dendrite . Nucleus . Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. .
