FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Rag A/B
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
34kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human RRAGA/B. AA range:264-313
特异性
Rag A/B Polyclonal Antibody detects endogenous levels of Rag A/B protein.
基因名称
RRAGA/RRAGB
蛋白名称
Ras-related GTP-binding protein A/B
别名
RRAGA;Ras-related GTP-binding protein A;Rag A;RagA;Adenovirus E3 14.7 kDa-interacting protein 1;FIP-1;RRAGB;Ras-related GTP-binding protein B;Rag B;RagB
Organism-1
Human
基因ID-1
10670;10325
SwissProt-1
Q7L523;Q5VZM2
Organism-2
Mouse
基因ID-2
68441;245670
Organism-3
Rat
基因ID-3
117044;100909655
SwissProt-3
Q63486;Q63487
背景
function:Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subcellular location:Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane.,subunit:Can occur as a homodimer, or form a heterodimer with RRAGC or RRAGD in a sequence-independent manner. Binds GTP. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein.,tissue specificity:Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.,
细胞定位
Cytoplasm . Nucleus . Lysosome . Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (PubMed:8995684, PubMed:9394008). Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684). .
