FGF-2 Polyclonal Antibody
¥680.00
Rac1/2/3/CDC42 Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2615936
- 产品信息
商品描述
靶点-Target
Rac1/2/3/CDC42
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
26kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Rac1/CDC42. AA range:38-87
特异性
Rac1/2/3/CDC42 Polyclonal Antibody detects endogenous levels of Rac1/2/3/CDC42 protein.
基因名称
RAC3
蛋白名称
Ras-related C3 botulinum toxin substrate 3
别名
RAC1;TC25;MIG5;Ras-related C3 botulinum toxin substrate 1;Cell migration-inducing gene 5 protein;Ras-like protein TC25;p21-Rac1;RAC2;Ras-related C3 botulinum toxin substrate 2;GX;Small G protein;p21-Rac2;RAC3;Ras-related C3 bot
Organism-1
Human
基因ID-1
5879;5880;5881;998
SwissProt-1
P63000;P15153;P60763;P60953
Organism-2
Mouse
基因ID-2
19353;19354;170758;12540
Organism-3
Rat
基因ID-3
363875;64465
SwissProt-3
Q6RUV5;Q8CFN2
背景
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Cytoplasm . Cell projection, lamellipodium . Cell projection, dendrite . Cell junction, synapse . Nucleus . Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (PubMed:1903399). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Localizes to the lamellipodium in a SH3RF1-dependent manner (By similarity). In macrophages, cytoplasmic location increases upon CSF1 stimulation (By similarity). Activation by GTP-binding promotes nuclear localization (PubMed:12551911). .
