FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PUMA
反应性
Human,Mouse,Rat
应用
WB IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
23kD
推荐稀释比
WB 1:500-2000;IF 1:100-300;ELISA 1:5000-20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169
特异性
PUMA Polyclonal Antibody detects endogenous levels of PUMA protein.
基因名称
BBC3
蛋白名称
Bcl-2-binding component 3
别名
BBC3;PUMA;Bcl-2-binding component 3;JFY-1;p53 up-regulated modulator of apoptosis
Organism-1
Human
基因ID-1
27113
SwissProt-1
Q9BXH1
Organism-2
Mouse
基因ID-2
170770
SwissProt-2
Q99ML1
Organism-3
Rat
基因ID-3
317673
SwissProt-3
Q80ZG6
背景
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],
细胞定位
Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release.
