FGF-2 Polyclonal Antibody
¥680.00
PTTG1/2/3 Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2615891
- 产品信息
商品描述
靶点-Target
PTTG1/2/3
反应性
Human,Rat,Mouse,
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
30kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human PTTG1. AA range:111-160
特异性
PTTG1/2/3 Polyclonal Antibody detects endogenous levels of PTTG1/2/3 protein.
基因名称
PTTG1
蛋白名称
Securin
别名
PTTG1;EAP1;PTTG;TUTR1;Securin;Esp1-associated protein;Pituitary tumor-transforming gene 1 protein;Tumor-transforming protein 1;hPTTG
Organism-1
Human
基因ID-1
9232
SwissProt-1
O95997
Organism-2
Mouse
SwissProt-2
Q9CQJ7
背景
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been fo
细胞定位
Cytoplasm. Nucleus.
