FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PTP1B
反应性
Human,Mouse,Rat,Monkey
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
49kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human PTP1B. AA range:16-65
特异性
PTP1B Polyclonal Antibody detects endogenous levels of PTP1B protein.
基因名称
PTPN1
蛋白名称
Tyrosine-protein phosphatase non-receptor type 1
别名
PTPN1;PTP1B;Tyrosine-protein phosphatase non-receptor type 1;Protein-tyrosine phosphatase 1B;PTP-1B
Organism-1
Human
基因ID-1
5770
SwissProt-1
P18031
Organism-2
Mouse
基因ID-2
19246
SwissProt-2
P35821
Organism-3
Rat
基因ID-3
24697
SwissProt-3
P20417
背景
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Interacts with EPHA3 at the cell membrane.
