FGF-2 Polyclonal Antibody
¥680.00
PTP IA-2β Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2615886
- 产品信息
商品描述
靶点-Target
PTP IA-2β
反应性
Human,Mouse,Rat
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
111kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human PTPRN2. AA range:206-255
特异性
PTP IA-2β Polyclonal Antibody detects endogenous levels of PTP IA-2β protein.
基因名称
PTPRN2
蛋白名称
Receptor-type tyrosine-protein phosphatase N2
别名
PTPRN2;KIAA0387;Receptor-type tyrosine-protein phosphatase N2;R-PTP-N2;Islet cell autoantigen-related protein;IAR;ICAAR;Phogrin
Organism-1
Human
基因ID-1
5799
SwissProt-1
Q92932
Organism-2
Mouse
基因ID-2
19276
SwissProt-2
P80560
Organism-3
Rat
基因ID-3
29714
SwissProt-3
Q63475
背景
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],
细胞定位
Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein . Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity). .; [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane .
