FGF-2 Polyclonal Antibody
¥680.00
PKA IIβ reg Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2615760
- 产品信息
商品描述
靶点-Target
PKA IIβ reg
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
46kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human PKA-R2 beta. AA range:79-128
特异性
PKA IIβ reg Polyclonal Antibody detects endogenous levels of PKA IIβ reg protein.
基因名称
PRKAR2B
蛋白名称
cAMP-dependent protein kinase type II-beta regulatory subunit
别名
PRKAR2B;cAMP-dependent protein kinase type II-beta regulatory subunit
Organism-1
Human
基因ID-1
5577
SwissProt-1
P31323
Organism-2
Mouse
基因ID-2
19088
SwissProt-2
P31324
Organism-3
Rat
基因ID-3
24679
SwissProt-3
P12369
背景
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activ
细胞定位
Cytoplasm . Cell membrane . Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
