FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Pim-1
反应性
Human,Mouse,Rat
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
50kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Pim-1. AA range:281-330
特异性
Pim-1 Polyclonal Antibody detects endogenous levels of Pim-1 protein.
基因名称
PIM1
蛋白名称
Serine/threonine-protein kinase pim-1
别名
PIM1;Serine/threonine-protein kinase pim-1
Organism-1
Human
基因ID-1
5292
SwissProt-1
P11309
Organism-2
Mouse
SwissProt-2
P06803
Organism-3
Rat
基因ID-3
24649
SwissProt-3
P26794
背景
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011],
细胞定位
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane.
