FGF-2 Polyclonal Antibody
¥680.00
PI 3-kinase p101 Polyclonal Antibody
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2615726
- 产品信息
商品描述
靶点-Target
PI 3-kinase p101
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
100kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human PIK3R5. AA range:695-744
特异性
PI 3-kinase p101 Polyclonal Antibody detects endogenous levels of PI 3-kinase p101 protein.
基因名称
PIK3R5
蛋白名称
Phosphoinositide 3-kinase regulatory subunit 5
别名
PIK3R5;Phosphoinositide 3-kinase regulatory subunit 5;PI3-kinase regulatory subunit 5;PI3-kinase p101 subunit;Phosphatidylinositol 4;5-bisphosphate 3-kinase regulatory subunit;PtdIns-3-kinase regulatory subunit;Protein FOAP-2;PtdIns-
Organism-1
Human
基因ID-1
23533
SwissProt-1
Q8WYR1
Organism-2
Mouse
基因ID-2
320207
SwissProt-2
Q5SW28
背景
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011],
细胞定位
Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein . Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. .
