FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PHKA1/2
反应性
Human,Mouse,Rat
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
137kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human KPB1/2. AA range:31-80
特异性
PHKA1/2 Polyclonal Antibody detects endogenous levels of PHKA1/2 protein.
基因名称
PHKA1/PHKA2
蛋白名称
Phosphorylase b kinase regulatory subunit alpha skeletal muscle isoform/Phosphorylase b kinase regulatory subunit alpha liver isoform
别名
PHKA1;PHKA;Phosphorylase b kinase regulatory subunit alpha;skeletal muscle isoform;Phosphorylase kinase alpha M subunit;PHKA2;PHKLA;PYK;Phosphorylase b kinase regulatory subunit alpha, liver isoform;Phosphorylase kinase alpha L sub
Organism-1
Human
基因ID-1
5255;5256
SwissProt-1
P46020;P46019
Organism-2
Mouse
基因ID-2
18679;110094
Organism-3
Rat
基因ID-3
64561
SwissProt-3
Q64649
背景
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript varian
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side .
