FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PERK
反应性
Human,Mouse,Rat
应用
IF,WB,IHC,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
125kD
推荐稀释比
IF 1:50-200;WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;Not yet tested in other applications;
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human EIF2AK3. AA range:947-996
特异性
PERK Polyclonal Antibody detects endogenous levels of PERK protein.
基因名称
EIF2AK3
蛋白名称
Eukaryotic translation initiation factor 2-alpha kinase 3
别名
EIF2AK3;PEK;PERK;Eukaryotic translation initiation factor 2-alpha kinase 3;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK
Organism-1
Human
基因ID-1
9451
SwissProt-1
Q9NZJ5
Organism-2
Mouse
SwissProt-2
Q9Z2B5
Organism-3
Rat
基因ID-3
29702
SwissProt-3
Q9Z1Z1
背景
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],
细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
