FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PAK4/5/6
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
80kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human PAK4/5/6. AA range:441-490
特异性
PAK4/5/6 Polyclonal Antibody detects endogenous levels of PAK4/5/6 protein.
基因名称
PAK4 PAK5 PAK6
蛋白名称
Serine/threonine-protein kinase PAK 4
别名
PAK4;KIAA1142;Serine/threonine-protein kinase PAK 4;p21-activated kinase 4;PAK-4
Organism-1
Human
基因ID-1
10298
SwissProt-1
O96013;Q9P286;Q9NQU5
Organism-2
Mouse
基因ID-2
70584
SwissProt-2
Q8BTW9
背景
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. .
