FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PAF-R
反应性
Human,Mouse,Rat
应用
IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
39kD
推荐稀释比
IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications;
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243
特异性
PAF-R Polyclonal Antibody detects endogenous levels of PAF-R protein.
基因名称
PTAFR
蛋白名称
Platelet-activating factor receptor
别名
PTAFR;PAFR;Platelet-activating factor receptor;PAF-R;PAFr
Organism-1
Human
基因ID-1
5724
SwissProt-1
P25105
Organism-2
Mouse
基因ID-2
19204
SwissProt-2
Q62035
Organism-3
Rat
基因ID-3
58949
SwissProt-3
P46002
背景
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
细胞定位
Cell membrane ; Multi-pass membrane protein .
