FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
p15
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
14kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:40000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human p15 INK. AA range:89-138
特异性
p15 Polyclonal Antibody detects endogenous levels of p15 protein.
基因名称
CDKN2B
蛋白名称
Cyclin-dependent kinase 4 inhibitor B
别名
CDKN2B;MTS2;Cyclin-dependent kinase 4 inhibitor B;Multiple tumor suppressor 2;MTS-2;p14-INK4b;p15-INK4b;p15INK4B
Organism-1
Human
基因ID-1
1030
SwissProt-1
P42772
Organism-2
Mouse
基因ID-2
12579
SwissProt-2
P55271
Organism-3
Rat
基因ID-3
25164
SwissProt-3
P55272
背景
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Also found in the nucleus.
