FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
N-Shc
反应性
Human,Mouse,Rat
应用
IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
48kD
推荐稀释比
IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SHC3. AA range:291-340
特异性
N-Shc Polyclonal Antibody detects endogenous levels of N-Shc protein.
基因名称
SHC3
蛋白名称
SHC-transforming protein 3
别名
SHC3;NSHC;SHCC;SHC-transforming protein 3;Neuronal Shc;N-Shc;Protein Rai;SHC-transforming protein C;Src homology 2 domain-containing-transforming protein C3;SH2 domain protein C3
Organism-1
Human
基因ID-1
53358
SwissProt-1
Q92529
Organism-2
Mouse
基因ID-2
20418
SwissProt-2
Q61120
Organism-3
Rat
SwissProt-3
O70143
背景
function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.,tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.,
细胞定位
cytosol,plasma membrane,
