FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Nephrin
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Calculated)
135kD
推荐稀释比
WB 1:500-2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human Nephrin. AA range:843-892
特异性
Nephrin Polyclonal Antibody detects endogenous levels of Nephrin protein.
基因名称
NPHS1
蛋白名称
Nephrin
别名
NPHS1;NPHN;Nephrin;Renal glomerulus-specific cell adhesion receptor
Organism-1
Human
基因ID-1
4868
SwissProt-1
O60500
Organism-2
Mouse
基因ID-2
54631
SwissProt-2
Q9QZS7
Organism-3
Rat
基因ID-3
64563
SwissProt-3
Q9R044
背景
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009],
细胞定位
Cell membrane ; Single-pass type I membrane protein . Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane. .
