FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MYSM1
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
95kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569
特异性
MYSM1 Polyclonal Antibody detects endogenous levels of MYSM1 protein.
基因名称
MYSM1
蛋白名称
Histone H2A deubiquitinase MYSM1
别名
MYSM1;KIAA1915;Histone H2A deubiquitinase MYSM1;2A-DUB;Myb-like;SWIRM and MPN domain-containing protein 1
Organism-1
Human
基因ID-1
114803
SwissProt-1
Q5VVJ2
Organism-2
Mouse
SwissProt-2
Q69Z66
背景
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.,function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase M67A family. MYSM1 subfamily.,similarity:Contains 1 MPN (JAB/Mov34) domain.,similarity:Contains 1 SANT domain.,similarity:Contains 1 SWIRM domain.,subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.,
细胞定位
Nucleus . Cytoplasm . Localizes to the cytoplasm in response to bacterial infection. .
