FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Sin3B
反应性
Human,Mouse
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
130kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human SIN3B. AA range:221-270
特异性
Sin3B Polyclonal Antibody detects endogenous levels of Sin3B protein.
基因名称
SIN3B
蛋白名称
Paired amphipathic helix protein Sin3b
别名
SIN3B;KIAA0700;Paired amphipathic helix protein Sin3b;Histone deacetylase complex subunit Sin3b;Transcriptional corepressor Sin3b
Organism-1
Human
基因ID-1
23309
SwissProt-1
O75182
Organism-2
Mouse
SwissProt-2
Q62141
背景
function:Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.,similarity:Contains 3 PAH (paired amphipathic helix) repeats.,subunit:Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SDS3 enhances the interaction with HDAC1 to form a complex. Interacts with MAD3, MAD4, MAEL, REST and SETDB1 (By similarity). Interacts with HCFC1.,
细胞定位
Nucleus .
