FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MRE11
反应性
Human,Mouse,Rat,Monkey
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
80kD
推荐稀释比
WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
The antiserum was produced against synthesized peptide derived from human MRE11. AA range:230-279
特异性
MRE11 Polyclonal Antibody detects endogenous levels of MRE11 protein.
基因名称
MRE11A
蛋白名称
Double-strand break repair protein MRE11A
别名
MRE11A;HNGS1;MRE11;Double-strand break repair protein MRE11A;Meiotic recombination 11 homolog 1;MRE11 homolog 1;Meiotic recombination 11 homolog A;MRE11 homolog A
Organism-1
Human
基因ID-1
4361
SwissProt-1
P49959
Organism-2
Mouse
基因ID-2
17535
SwissProt-2
Q61216
Organism-3
Rat
基因ID-3
64046
SwissProt-3
Q9JIM0
背景
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents. .
